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    How to Make IVF Successful the First Time: Understanding Success Rates & Factors


    How to Make IVF Successful the First Time: Understanding Success Rates & Factors

    Updated on 18 July 2023

    Medically Reviewed by

    Kusum Sabharwal

    Obstetrician & Gynecologist - MBBS| DGO

    View Profile

    Roohi and Rahul had always dreamt of starting their own family, but fertility challenges prevented their dreams from coming true. But when God closes one door, he opens a window. And In-vitro Fertilization (IVF) was no less than a remarkable window of hope for them. But the path to parenthood wasn’t easy still- success rates, factors, treatments – it was a lot to take in! And thus began their quest on how to make IVF successful the first time.

    From understanding the crucial factors that play a role in IVF to the success rate of IVF first time, we will understand all these aspects. What’s more, we will also take into account why IVF fails first time and how you can avoid it in order to maximize your chances of a successful pregnancy. Get ready to embark on a path of hope, discovery, and new beginnings!

    What is the Success Rate of IVF First Time?

    Let us try to break down IVF success rate in first attempt on the basis of singleton births (the birth of one child per IVF cycle) and non-singleton births (twins, triplets or higher) as per different age ranges.

    For singletons the percentage of live births per egg retrieval is as follows:

    Below 35 years old: 41.6%

    35-37 years old: 29.6%

    38-40 years old: 18.7%

    41-42 years old: 9.2%

    Over42 years old: 2.8%

    For all live births, including singletons and non-singletons using patient’s own eggs, the success rates are as follows:

    Below 35 years old: 44.6%

    35-37 years old: 31.5%

    38-40 years old: 19.9%

    41-42 years old: 9.7%

    Over 42 years old: 2.9%

    When it comes to the success rate of IVF first time in India, the number lies between 30-35% for women below the age of 35 years.

    You may also like: After How Many Weeks IVF Pregnancy Is Safe: Understanding The Ideal Timeline

    What are the Factors Affecting IVF Success Rate in First Attempt?

    In order to understand how to make IVF successful the first time, it’s important to understand the factors that affect the success rates of IVF. These include:

    1. Age of the Woman

    Age is one of the most critical factors affecting IVF success. Younger women generally have better-quality eggs, which are more likely to result in successful fertilization and embryo development. As a woman's age increases, the quantity and quality of her eggs decline, reducing the chances of a successful pregnancy.

    2. Embryo Quality

    The quality of the embryos created during the IVF process plays a crucial role. High-quality embryos are more likely to implant successfully in the uterus and result in a viable pregnancy. Embryo quality is determined by factors such as the appearance of the embryos under the microscope, their developmental stage, and their genetic health.

    3. Underlying Cause of Infertility

    The reason for infertility can impact IVF success. Some infertility issues, such as ovulation disorders or male factor infertility, may respond well to IVF treatment. However, certain conditions like severe uterine abnormalities or advanced age-related fertility decline may reduce the chances of success.

    4. Lifestyle Factors

    Lifestyle choices can also influence IVF success. Factors such as smoking, excessive alcohol consumption, obesity, and a poor diet can negatively affect fertility and the success of IVF. Maintaining a healthy lifestyle can optimize the chances of a successful outcome.

    5. Fertility Clinic Expertise

    The experience and expertise of the fertility clinic and its medical team play a significant role in IVF success. Well-established clinics with experienced fertility specialists and embryologists tend to have higher success rates. These professionals can tailor the treatment approach to individual needs, increasing the chances of a successful pregnancy.

    It's important to note that IVF success is a complex interplay of various factors, and individual circumstances can vary greatly. Couples undergoing IVF should have a detailed discussion with their fertility specialist to assess their unique situation and receive personalized guidance to optimise their IVF success rate in first attempt.

    Why IVF Fails First Time?

    Couples opting for IVF may not always succeed on the first attempt. Several reasons can contribute to failed first IVF attempt such as:

    1. Embryo Quality Issues

    One of the main reasons for IVF failure is embryo-related problems. Even though the embryos may look viable, they might have chromosomal abnormalities or other developmental issues that prevent successful implantation or lead to early pregnancy loss.

    2. Implantation Failure

    Successful IVF requires the embryo to implant into the uterine lining properly. Sometimes, the embryo may not implant adequately due to issues with the uterine lining, immune system factors, or other underlying conditions, leading to IVF failure.

    3. Underlying Health Conditions

    Certain medical conditions, such as polycystic ovary syndrome (PCOS), endometriosis, or uterine abnormalities, can negatively impact IVF success. These conditions may affect egg quality, hormonal balance, or the ability of the uterus to support implantation.

    4. Age of the Woman

    As mentioned earlier, a woman's age significantly affects IVF success. Older women, especially those over 35, have a reduced ovarian reserve and poorer egg quality, which can decrease the chances of successful fertilization, implantation, and healthy pregnancy.

    5. Lifestyle Factors

    Lifestyle choices can also affect IVF outcomes. Factors like smoking, excessive alcohol consumption, obesity, and stress can adversely influence fertility and reduce the chances of successful IVF.

    It's crucial to remember that IVF success is not always immediate, and multiple factors may come into play. The journey to parenthood through IVF can involve several attempts before achieving a successful pregnancy.

    How to Make IVF Successful the First Time?

    Increasing the success rate of IVF first time involves a combination of lifestyle choices and medical strategies. Here are eight ways to boost your odds:

    1. Pre-IVF Health Optimization

    Prior to starting IVF, focus on optimizing your overall health. Maintain a nutritious diet, exercise regularly, and reduce stress. Avoid smoking, consuming alcohol, and recreational drugs, as they can negatively impact fertility.

    2. Undergo Comprehensive Fertility Testing

    Complete fertility testing before starting IVF. This includes assessing hormone levels, evaluating egg quality, and conducting sperm analysis. Identifying any underlying issues will help the medical team tailor the treatment plan accordingly.

    3. Consider Genetic Testing

    Preimplantation Genetic Testing (PGT) can be beneficial, especially for couples with a history of genetic disorders or advanced maternal age. PGT can identify chromosomally healthy embryos for transfer, improving the chances of a successful pregnancy.

    4. Choose a Reputable Fertility Clinic

    Research and select a well-established fertility clinic with experienced specialists and a track record of successful IVF outcomes. A reputable clinic will provide personalized care and the latest advancements in reproductive technology.

    5. Optimize Ovulation Stimulation

    Ovulation stimulation is a critical step in IVF. Work closely with your doctor to determine the ideal medication protocol for stimulating egg production. Proper monitoring ensures the collection of mature and high-quality eggs.

    6. Individualized Embryo Transfer

    Discuss with your fertility specialist the appropriate number of embryos to transfer. Transferring too many embryos can lead to multiple pregnancies, which carry higher risks. On the other hand, transferring too few embryos might reduce the chances of success.

    7. Endometrial Preparation

    Ensure the uterus is adequately prepared to receive the embryos. Your doctor may suggest hormone supplementation or other techniques to optimize the uterine lining for successful implantation.

    8. Emotional Support and Mindfulness

    IVF can be emotionally taxing. Seek support from loved ones, join support groups, or consider counseling. Reducing stress through mindfulness techniques like meditation and yoga can positively impact fertility.

    You may also like: Sleeping Position After IVF & Other Precautions That Can Boost Your Chances of Success


    1. Does IVF usually fail first time?

    IVF can fail on the first attempt, but it varies for each individual. Success rates depend on factors such as the woman's age, underlying infertility causes, embryo quality, and overall health. While some may achieve success in the first round, others may need multiple attempts.

    2. What to do after first failed IVF?

    After a first failed IVF, it's essential to seek guidance from your fertility specialist. They will review the cycle and may recommend changes to the treatment plan based on any insights gained. Take time to emotionally recover, consider counseling if needed, and discuss any lifestyle adjustments.

    3. What are the signs of successful IVF?

    Signs of successful IVF may include early pregnancy symptoms such as implantation bleeding, breast tenderness, mild cramping, and nausea. Around two weeks after embryo transfer, a blood test can confirm rising hCG hormone levels, indicating pregnancy.

    The Bottomline

    In conclusion, embarking on the journey of IVF can be a transformative experience filled with hope and possibilities. Understanding the key factors influencing IVF success rates empowers individuals and couples to make informed decisions on how to make IVF successful the first time. While there are no guarantees, the combination of expert medical guidance, lifestyle optimization, and emotional support lays the groundwork for a rewarding IVF journey, bringing dreams of parenthood closer to reality.


    1. Dabbagh Rezaeiyeh R, Mehrara A, Mohammad Ali Pour A, Fallahi J, Forouhari S. (2022). Impact of Various Parameters as Predictors of The Success Rate of In Vitro Fertilization. Int J Fertil Steril.
    2. All SART Member Clinics. (2020). Final National Summary Report for 2020. SART
    3. Eskew AM, Jungheim ES. (2017). A History of Developments to Improve in vitro Fertilization. Mo Med.
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    Medically Reviewed by

    Kusum Sabharwal

    Obstetrician & Gynecologist - MBBS| DGO

    View Profile

    Written by

    Mylo Editor

    Official account of Mylo Editor

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